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Focus on the processing of sensitive materials

The supercritical CO2 extraction and other processes based on CO2 as a solvent are of high interest for different areas of the pharmaceutical industry. This is mainly due to the unique properties of CO2, which allow the extraction of sensitive substances selectively and gently. Natex is experienced in providing everyone access to these special properties and provides the biggest and most advanced equipment in the pharmaceutical industry, regularly setting and expanding the cGMP standard for this high-pressure industry.

Clean, Standardized, and Repeatable

The extraction can take place at moderate temperatures, and the CO2 vaporizes without any residue in ambient conditions. This enables the production of high-quality pharmaceutical substances without any residues. It also offers potential for reducing process steps considerably, cleaning from impurities, and increasing the bioavailability of drugs. The gentle nature of supercritical CO2 extraction ensures that the integrity of sensitive compounds is maintained, making it an ideal method for producing high-purity pharmaceutical products.

Industrial Applications and Developments

Supercritical CO2 extraction is versatile and can be applied to various industrial processes within the pharmaceutical sector. Some of the key applications include:

Industrial scale plant pharma
  • Extraction of Active Pharmaceutical Ingredients (APIs): Extracting APIs from natural raw materials and medicinal plants. This process allows for selective extraction of specific compounds that are essential for the formulation of pharmaceutical products.

  • Cleaning, Purification, or Fractionation of intermediate products: This helps in removing impurities and achieving the desired purity and quality of the final products.

  • Removal of Residues: Removing organic solvents, monomers, oligomers, and other residues from medical products and tools. This ensures that the products are safe and free from harmful contaminants.

  • Microparticle Formation: Formation, encapsulation, and impregnation of microparticles. This process is used for the development of drug delivery systems and other pharmaceutical applications.

Fulfilling All Required Regulations and Requirements

Pharmaceutical applications require the highest degree of repeatable processing, cleaning, safety, and traceability. NATEX plants fulfill customer-specific requirements in accordance with regulatory organizations such as the European Medicines Agency (EMA), the US Food and Drug Administration (FDA), the Medicines and Healthcare products Regulatory Agency (MHRA), and others. Compliance with these regulations ensures that the extraction processes meet the highest standards of quality and safety.

World-Leading Partner

NATEX’s position as an established supplier for the pharmaceutical industry is continuously manifested through raising the bar for cGMP in high-pressure applications. To fulfill the special requirements and validated cleaning possibilities, we have been developing unique, hygienic solutions for each part of the plant. This is why we work closely with selected suppliers to ensure ongoing improvement. Our commitment to innovation and quality makes us a trusted partner for pharmaceutical companies worldwide.

Pharmaceuticals Anlage

Possible Products and Extracts

Supercritical CO2 extraction can be used to produce a wide range of pharmaceutical products and extracts, including:

Pharmaceuticals Products
  • Carotenoids: Important for their antioxidant properties and used in various pharmaceutical formulations.

  • Omega 3 & Omega 6 Fatty Acids: Essential fatty acids that are beneficial for health and used in dietary supplements and pharmaceutical products.

  • Lycopene: A powerful antioxidant used in various health products.

  • Curcuminoids: Bioactive compounds from turmeric with anti-inflammatory and antioxidant properties.

  • Moringa: Known for its nutritional and medicinal benefits.

  • Cannabis: Extracts used for their therapeutic properties.

  • Calendula / Marigold: Used for their healing and anti-inflammatory properties.

  • Borage, Rosehip, Green-Lipped Mussel, Artemisia-annua, Microalgae, Frankincense: These are used for their various health benefits and are included in pharmaceutical and nutraceutical products.